|
rs9865108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we sought to investigate the top 21 SNPs (rs10507454, rs11897156, rs11897991, rs12325203, rs12541835, rs13395322, rs1525035, rs16936892, rs17010027, rs17045859, rs17136827, rs1866525, rs2045590, rs4547758, rs4655688, rs7107438, rs761353, rs8127139, rs9312305, rs9407874 and rs9865108) from a genome-wide association study of essential hypertension in Mongolians.
|
28682143 |
2018 |
|
rs9794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found a potential SNP-SNP interaction between rs2016520 and rs979</span>4</span>; subjects with TC or CC of rs2016520 and CG or GG of rs9794 genotype have the lowest EH risk, compared to subjects with TT of rs2016520 and CC of rs9794 genotype; OR (95%CI) was 0.32 (0.23-0.62) after covariate adjustment.
|
26613934 |
2016 |
|
rs9607267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the HMOX1 gene was also significantly associated with the risk of EH.
|
19886851 |
2009 |
|
rs953038635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study.
|
21053180 |
2010 |
|
rs945393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association was identified between rs10803414 and EH in the Mongolian population (P < .05) and rs945393 and EH in the Han population (P < .01).
|
22578033 |
2012 |
|
rs9407874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we sought to investigate the top 21 SNPs (rs10507454, rs11897156, rs11897991, rs12325203, rs12541835, rs13395322, rs1525035, rs16936892, rs17010027, rs17045859, rs17136827, rs1866525, rs2045590, rs4547758, rs4655688, rs7107438, rs761353, rs8127139, rs9312305, rs9407874 and rs9865108) from a genome-wide association study of essential hypertension in Mongolians.
|
28682143 |
2018 |
|
rs9332242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) of CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), and CYP2C19 (rs4244285) are associated with susceptibility to EH in Russian population.
|
28513222 |
2017 |
|
rs911154679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Constitutively activated GRK4 gene variants (R65L, A142V, and A486V), by themselves or by their interaction with other genes involved in blood pressure regulation, are associated with essential hypertension and/or salt-sensitive hypertension in several ethnic groups.
|
20153824 |
2010 |
|
rs890293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were identified among the SNPs rs890293 (OR = 2.17, 95%CI 1.30-3.65), rs2280275 (OR = 1.59, 95%CI 1.10-2.37) and rs11572325 (OR = 1.89, 95%CI 1.22-2.95) and the risk of EH in females from the Kursk population.
|
30518987 |
2019 |
|
rs889299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between the rs889299 SNP and functional SNPs in other genes influencing aldosterone-responsive distal tubular electrolyte transport may be important in the etiology of essential hypertension.
|
18184758 |
2008 |
|
rs883062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the EH group than in the NT1 group (p<0.0001) or the NT2 group (p<0.0001).
|
18037771 |
2007 |
|
rs879922
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Risk genotypes of rs2074192 (TT+CT, OR = 1.72, 95% CI: 1.17-2.53), rs2106809 (TT, OR = 1.71, 95% CI: 1.13-2.58), rs4240157 (CC+CT, OR = 1.99, 95% CI: 1.17-3.41), rs4646155 (TT+CT, OR = 1.94, 95% CI: 1.06-3.54), rs4646188 (TT+CT, OR = 3.25, 95% CI: 1.95-5.41), rs4830542 (CC+CT, OR = 1.88, 95% CI: 1.10-3.23), and rs879922 (CC+CG, OR = 4.86, 95% CI: 2.74-8.64) were associated with EH.
|
30542083 |
2019 |
|
rs879922
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Five SNPs (rs1514283, rs4646155, rs4646176, rs2285666, and rs879922) in ACE2 gene were determined to significantly associate with EH in female participants, while no SNP locus was linked to male group.
|
30335025 |
2018 |
|
rs879922
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Participants carrying T allele (TT + CT) of rs2074192 (P = 0.006), rs4646155 (P = 0.030) and rs4646188 (P < 0.001), C allele (CT + CT or CC + CG) of rs4240157 (P = 0.012), rs4830542 (P = 0.020) and rs879922 (P < 0.001) and TT genotype of rs2106809 (P = 0.012) were associated with EH.
|
30342552 |
2018 |
|
rs876493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we explored the association of two common PNMT promoter single-nucleotide polymorphisms (SNPs) G-367A (rs3764351) and G-161A (rs876493) and their haplotypes with the risk of essential hypertension in a Han Chinese population, using 316 pairs of age-, sex-, and geographically matched essential hypertension patients and normotensive controls.
|
21866188 |
2011 |
|
rs867667840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT.
|
15824464 |
2004 |
|
rs8192678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association between the PPARGC1A Gly482Ser polymorphism and LV morphology and performance in essential hypertension, with special consideration of fibrosis intensity.
|
24718382 |
2014 |
|
rs8192678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There were no associations of the G482S and +1302G>A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes.
|
15824463 |
2004 |
|
rs796145467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study examined whether C1773T/LDLR was associated with essential hypertension in a Japanese population.
|
11317192 |
2001 |
|
rs7955866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Confounding factors (sex, age, BMI, smoking, and drinking) were adjusted in the non-logistic regression, and the results showed that rs7955866</span> and rs3812822 polymorphisms were independently associated with the risk of developing EH (P < 0.05).
|
29336609 |
2018 |
|
rs7909236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combination of genotypes CYP2C8 rs7909236 TT and CYP2C19 rs4244285 GG was associated with increased EH risk (OR 3.34 95%CI 1.48-7.51, P = 0.004).
|
28513222 |
2017 |
|
rs777986489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT.
|
15824464 |
2004 |
|
rs777208537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.
|
11230366 |
2001 |
|
rs772658003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Ala270Ser polymorphism was significantly associated with essential hypertension in the present sample.
|
17060063 |
2006 |
|
rs772187470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT.
|
15824464 |
2004 |